Thursday, 18 October 2012

18 October, 2012 Clippings


Cow’s milk – an unlikely HIV/AIDS cure?
A study has claimed that antibodies from cow’s milk that protect against HIV can be potentially developed into affordable creams that can help protect humans against the infection. Dr Marit Kramski from Melbourne University found that when pregnant cows were vaccinated with a HIV protein, they produced high antibodies against the disease in their colostrum – the first milk produced after giving birth to a calf.
The antibodies bind to the HIV virus and inhibit the virus from entering human cells, Dr Kramski and her colleagues discovered.
‘We think the antibodies bind to the surface of the virus and block the protein which needs to be freed to get in contact with human cells — like a key and lock system. If the key’s not accessible or you change the key, you can’t open the door,’ Kramski said. Dr Kramski said that the method can generate up to one kilogram of antibodies from a single cow leading to an affordable prevention treatment for HIV. ‘It’s a very cheap and easy way to produce a lot of antibodies,’ she added.
The next step would be to test the effectiveness and safety of the milk before developing the antibodies into a cream that could be inserted in the vagina allowing women to protect themselves against contracting the virus during sex.
‘We have the antibodies at the moment — the next step will be formulation,’ Kramski said. ‘A lot of women, especially in Africa or South America, don’t have the power to say you need to use a condom before we have sex. The cream would give women the power to protect themselves,’ she added. ‘This milk looks like it can be a cheap, easy new prevention tool, because if you use drugs it’s really expensive,’ she said. Dr Kramski developed the milk in association with Australian biotechnology company Immuron Ltd.
18.10.2012
Alcoholic women have shorter lifespans
According to German researchers, the annual death rates of alcohol-dependent women are 460 percent higher than the non-drinking general population while male alcoholics have a 190 percent higher death rate than the general population.
‘Clinical data has revealed a higher proportion of individuals who have died than among the general population of the same age,’ explained Ulrich John, professor of epidemiology and social medicine at the University of Greifswald.
John and colleagues gathered a random sample of 4,070 respondents aged between 18 and 64 years. Of them, 153 were identified as alcohol dependent (AD). Of these, 149 (119 males, 30 females) were followed for 14 years.
‘Gender-specific data is rare, even among clinical samples. Furthermore, these studies have two main limitations,’ adds John, according to the journal Alcoholism: Clinical & Experimental Research.
‘First, we know that only a minority of AD individuals receive treatment. We lack knowledge about how this selection occurs. Second, we have no evidence about the potential effects of specialized alcoholism treatment on mortality among people who had been diagnosed AD,’ says John, according to a University Medicine statement.
‘We would like to know whether treatment might enhance survival time. For ethical reasons, no controlled trials are possible. Thus, longitudinal descriptive data as in this study are helpful,’ says John, study co-author. John adds that Germany is well-suited for this kind of research since it is mandatory for residents to provide vital status data.
‘Our data are also of international interest because researchers used the Composite International Diagnostic Interview (CIDI), which is an internationally and widely accepted instrument,’ he said.
18.10.2012





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