Woman in Madhya Pradesh delivers 10 babies - all
stillborn
Bhopal: In an extremely rare case, a 28-year-old woman in
Madhya Pradesh delivered 10 babies - but all stillborn, a doctor said Monday.
Anju Kushwaha from Koti village in Satna district was being
taken to the Sanjay Gandhi Memorial hospital, 125 km away in neighbouring Rewa
district, after she went into labour but she delivered nine stillborn babies on
the way.
 |
A doctor attending to the woman said the medical team was
awestruck when Anju's husband Sanjay presented before them the nine stillborn
babies.
When the medical team examined her, they found one more
foetus was in the woman's womb. It was delivered early Monday but again turned
out to be stillborn, said the hospital's assistant superintendent S.K. Pathak.
The doctors said it was a case of miscarriage followed by
"hyper stimulation syndrome", where fertility drugs stimulate the
ovaries to produce many egg sacs.
The woman was keeping well, doctors said.
17.12.2013
Targeting glucose can help in fight against seasonal
flu
Washington:
A new research has revealed that reducing glucose metabolism dials down
influenza viral infection in laboratory cell cultures, providing an entirely
new approach for combating seasonal flu.
While
annual flu shots are based on the U.S. Centers for Disease Control (CDC)'s
predictions of the viruses that will be in widest circulation each flu season,
the new approach targets one metabolic requirement of all influenza viruses:
glucose.
Reducing
viruses' glucose supply weakens the microbes' ability to infect host cells,
said Amy Adamson, Ph.D., and Hinissan Pascaline Kohio of the University of
North Carolina, Greensboro.
|
|
To
infect cells, the influenza virus is dependent upon the actions of the cell's
own proteins, and so another strategy for slowing viral infection would be to
target essential viral needs, for example, their dependence on cellular
glucose. Dr. Adamson and Kohio showed that influenza A infection can be
controlled in laboratory cultures of mammalian cells by altering glucose
metabolism.
When
the influenza virus initially infects a cell, and the virus is confined in an
endocytic vesicle, the viral proteins HA and M2 use the acidic environment
inside the vesicle to fuse the viral lipid envelope with that of the vesicle,
and then release the viral genome into the cytosol.
The
acidic pH that mediates these important viral process is established and
maintained by the cell's vacuolar-type H+ ATPase (V-ATPase) proton pump. The
researchers found that this dependence could be used to manipulate the
infection's success.
Dr.
Adamson and Kohio boosted glucose concentrations in the laboratory cell
cultures, and influenza infection rate concomitantly increased. Treating the
viral cells with a chemical that inhibits glucose metabolism significantly
decreased viral replication in the lab cultures.
The
researchers also demonstrated that the infection could be restored to high levels
simply by adding ATP, the major source of energy for cellular reactions,
bypassing the need for glucose .
The
research was presented at the American Society for Cell Biology (ASCB) annual
meeting in New Orleans.
17.12.2013
Success is most often achieved by those who don’t know that failure is inevitable
Coco
Chanel
No comments:
Post a Comment