India accounts for 60% of head and neck cancer cases, say experts
Owing to increased use of tobacco, India contributes to nearly 60 percent of head and neck cancer — inside the mouth, the nose, and the throat — patients worldwide and the number is expected to double by 2030, health experts said.
“Global contribution of head and neck cancer patients is 57.5 percent in India. Out of these 80,000 cases annually are cases of oral cancer,” said Kumar Prabhash from Tata Memorial Hospital in Mumbai told reporters.
“Tobacco is one of the major cause behind these cases of head and neck cancers. And we are estimating the number of cases to double by 2030,” added Sumit Goyal from Department of Medical Oncology at Rajiv Gandhi Cancer Institute in New Delhi.
Nimotuzumab is the first indigenously produced novel biologic developed by Bengaluru-based biotech major Biocon and introduced in India as BIOMAb EGFR forhead and neck cancer in 2006.
To examine its efficacy, the clinical study examined 536 locally advanced head and neck cancer patients aged between 18 to 80 years.
The results showed that patients who were administered Nimotuzumab combined with cisplatin drug — used for chemotherapy — and radiation, survived almost three times more than those who received only chemo and radiation. It also reduced the risk of disease progression by 26 percent.
Biomab has a unique bivalent binding, because of which it binds primarily at the site of cancer cells where there is over expression of the EGFR protein.
This is significant since this mechanism of action of Biomab ensures that only the cancerous cells are destroyed, unlike other targeted agents, ensuring that it does not cause additional toxicity, said Prabhash.
30.07.2018
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