2 March, 2015

Occasional fasting may help you live longer

Intermittent fasting may actually help people live longer and healthier, says a study.Fasting in mice has been shown to extend lifespan and to improve age-related diseases. 

"We found that intermittent fasting caused a slight increase in SIRT3, a well-known gene that promotes longevity and is involved in protective cell responses," said Michael Guo, a student at Harvard Medical School. 

The SIRT3 gene encodes a protein also called SIRT3 that belongs to a class of proteins known as sirtuins. 

Sirtuins, if increased in mice, can extend their lifespans. 

"The hypothesis is that if the body is intermittently exposed to low levels of oxidative stress, it can build a better response to it."  The intermittent fasting also decreases insulin levels in the participants, which means the diet could have an anti-diabetic effect as well. 

The group recruited 24 participants in the clinical trial. 

During a three-week period, the participants alternated one day of eating 25 percent of their daily caloric intake with one day of eating 175 percent of their daily caloric intake. 

To test antioxidant supplements, the participants repeated the diet but also included vitamin C and vitamin E. 

The beneficial sirtuin proteins such as SIRT3 and SIRT1, tended to increase as a result of the diet.  However, when antioxidants were supplemented on top of the diet, some of these increases disappeared.  "Most of the participants found that fasting was easier than the feasting day, which was a little bit surprising to me," Guo added. 

"The future studies should examine a larger cohort of participants and should include a larger number of genes in the participants." 

The study appeared in the journal Rejuvenation Research. 

Source: www.timesofindia.com

02.03.2015

How pollution could make you obese

Researchers have discovered a link between the levels of certain environmental pollutants that a person accumulates in his or her body and their level of obesity. 

"We found that people with higher levels of persistent organic pollutants (POPs) were quantitatively more obese and also showed higher levels of cholesterol and triglycerides," said lead author Juan Pedro Arrebola from the University of Granada in Spain. 

These factors are regarded as key risk factors for developing cardiovascular diseases. 

The researchers analysed the levels of pollutants accumulated in adipose tissue (fat) in nearly 300 men and women, who were attended in the surgery services of two hospitals in the province of Granada. 

The POPs can remain in the environment for years, even decades, without degrading. 

"Humans are exposed to POPs mainly through diet. Besides, POPs accumulate gradually in body fat, and this is the reason why the median levels in our study give us an idea of an individual's accumulated exposition over a number of years," Arrebola added. 

Using complex statistical methods, the scientists confirmed that the accumulated levels of several POPs were related to obesity and to serum levels of cholesterol and triglycerides. 

The findings were true irrespective of the gender, age, place of residence or smoking habits of participants in the survey. 

The study appeared in the journal Environmental Pollution.

Source: www.timesofindia.com

02.03.2015

The only time you mustn’t fail is the last time you try

Charles Kettering