Recommended low salt
intake harmful for health
Beware! Your average daily salt
intake as recommended by the Centers for Disease Control and Prevention (CDC)
in the US may actually be low - leading to harmful health outcomes.
A study finds evidence that the average daily sodium intake of most Americans is actually associated with better health outcomes than intake levels currently recommended by the CDC and major health departments.
A study finds evidence that the average daily sodium intake of most Americans is actually associated with better health outcomes than intake levels currently recommended by the CDC and major health departments.
"The study confirms that 2,645-4,945 mg of sodium per day actually results in more favourable health outcomes than the CDC's current recommendation of less than 2,300mg/day for healthy individuals under 50-years old, and less than 1,500 mg/day for most over 50 years," explained lead author Niels Graudal.
This study was a combined analysis of 25 individual studies which measured results from over 274,683 individuals.
The results are an important extension of the findings of a major 2013 Institute of Medicine report that cast doubt on the current CDC recommendations but failed to establish any specific optimum range of intake.
"Our results are in line with the IOM's concern that lower levels could produce harm and they provide a concrete basis for revising the recommended range in the best interest of public health," Graudal, a researcher at University of Copenhagen Hospital in Denmark, commented.
According to him, the good news is that around 95 per cent of the global population already consumes within the range we have found to generate the least instances of mortality and cardiovascular disease.
When consumption deviated from the 2,645 - 4,945 mg range, mortality increased, so that both excessively high and low consumption of sodium were associated with reduced survival, the study found.
The study, published in the American Journal of Hypertension, also found that there is little-to-no variation in health outcomes between individuals as long as their consumption remained within the ideal intake range (2,645-4,945 mg/day).
Source: www.timesofindia.com
14.04.2014
Drink coffee to ward off
Alzheimer’s
Researchers have demonstrated for
the first time that caffeine has a positive effect on tau deposits in
Alzheimer's disease.
Tau deposits, along with beta-amyloid plaques, are among the characteristic features of Alzheimer's disease. These protein deposits disrupt the communication of the nerve cells in the brain and contribute to their degeneration. Despite intensive research there is no drug available to date which can prevent this detrimental process.
Based on the results of Prof. Dr. Christa Muller from the University of Bonn, Dr. David Blum and their team, a new class of drugs may now be developed for the treatment of Alzheimer's disease.
Caffeine, an adenosine receptor antagonist, blocks various receptors in the brain which are activated by adenosine. Initial results of the team of researchers had already indicated that the blockade of the adenosine receptor subtype A2A in particular could play an important role.
Initially, Prof. Muller and her colleagues developed an A2A antagonist in ultrapure and water-soluble form (designated MSX-3). This compound had fewer adverse effects than caffeine since it only blocks only the A2A adenosine receptor subtype, and at the same time it is significantly more effective.
Over several weeks, the researchers then treated genetically altered mice with the A2A antagonist. The mice had an altered tau protein which, without therapy, leads to the early development of Alzheimer's symptoms.
In comparison to a control group which only received a placebo, the treated animals achieved significantly better results on memory tests. The A2A antagonist displayed positive effects in particular on spatial memory. Also, an amelioration of the pathogenic processes was demonstrated in the hippocampus, which is the site of memory in rodents.
The results have been published online in the journal Neurobiology of Aging.
Source: www.timesofindia.com
14.04.2014
Never try to go back and repair the past which is IMPOSSIBLE ! But Be
prepared to construct the Future which is POSSIBLE..
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